Vibe genes? Natural(ish) language comes to protein, genome design software
摘要
中国研究团队开发出一款蛋白设计工具，可接收自然语言指令并生成具备指定功能的蛋白质，降低了使用门槛，但成功率有限。与此同时，Hugging Face宣布托管一款在DNA层面实现类似功能的工具。这被视为自然语言驱动生物设计的一次尝试，实际应用仍需实验室筛选验证。
Protein design tools may be getting increasingly sophisticated, but you still need a sophisticated understanding of protein structure for them to work. This can include knowing enzyme mechanisms down to the positions of specific amino acids, as well as the water molecules that also occupy the area where catalysis takes place. Once you specify these, the tools can build the rest of a protein around this target.
A large collaboration of researchers based in China, however, decided to bring protein design to the masses, making a tool that can take natural language prompts and use them to produce proteins with the function you specify. If your measure for success is a working protein, then the success rate may not be great. But they still manage to get the job done. And, in a separate announcement, Hugging Face shared that it's now hosting a tool that does similar things on the DNA level.
The equivalent of vibe coding may have come to protein design—at least if you have access to a lab where you can sort the good designs from the dozens of failed ones.
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